Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.50 |
| ▸ | MIF | P14174 | 4/20 | 0.48 |
| ▸ | CD74 | P04233 | 2/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CBX7 | O95931 | 1/20 | 0.40 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.40 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.40 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631935 | 0.92 | MET (0.50) | METMIFCD74TNIKPOLB | |
| SCHEMBL12241153 | 0.90 | MET (0.61) | METMIFCD74TNIKPOLB | |
| SCHEMBL2546891 | 0.89 | MET (0.51) | METMIFCD74POLBMEN1 | |
| SCHEMBL3631378 | 0.89 | ACHE (0.48) | METMIFCD74 | |
| SCHEMBL2549779 | 0.87 | MET (0.51) | METMIFCD74POLBMEN1 | |
| SCHEMBL12241080 | 0.87 | MET (0.51) | METMIFCD74POLBMEN1 | |
| Hydrochloric Acid SCHEMBL2542405 | 0.86 | MET (0.51) | METMIFCD74POLBMEN1 | |
| SCHEMBL12241083 | 0.86 | MEN1 (0.57) | METMIFCD74POLBMEN1 | |
| SCHEMBL12241095 | 0.86 | MET (0.55) | METMIFTNIKPOLBMEN1 | |
| SCHEMBL12241276 | 0.85 | MET (0.50) | METMIFCD74TNIKPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | claimed |
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |
| EP-2150551-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008148449-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | WO | disclosed |