Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.44 |
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632439 | 0.95 | HSD11B1 (0.43) | HSD11B1GAATRPV1RBP4TRPA1 | |
| SCHEMBL3634200 | 0.87 | HSD11B1 (0.47) | HSD11B1GAATRPV1RBP4TRPA1 | |
| SCHEMBL3631509 | 0.86 | GAA (0.48) | HSD11B1GAATRPV1RBP4TRPA1 | |
| SCHEMBL3632673 | 0.84 | GAA (0.46) | HSD11B1GAATRPV1RBP4TRPA1 | |
| SCHEMBL3633963 | 0.83 | GAA (0.45) | HSD11B1GAATRPV1RBP4TRPA1 | |
| SCHEMBL3632661 | 0.79 | HSD11B1 (0.52) | HSD11B1GAATRPV1RBP4TRPA1 | |
| SCHEMBL1735664 | 0.79 | HSD11B1 (0.48) | HSD11B1GAATRPV1RBP4TRPA1 | |
| SCHEMBL3623860 | 0.79 | HSD11B1 (0.52) | HSD11B1GAATRPV1RBP4TRPA1 | |
| SCHEMBL3213850 | 0.74 | HSD11B1 (0.78) | HSD11B1 | |
| SCHEMBL3628487 | 0.73 | TRPV1 (0.47) | HSD11B1TRPV1RBP4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142533-A1 | IMIDAZOLIDINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | claimed |
| WO-2008119657-A1 | IMIDAZOLIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | WO | claimed |
| EP-2142533-A1 | IMIDAZOLIDINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119657-A1 | IMIDAZOLIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | WO | disclosed |