Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.46 |
| ▸ | RBP4 | P02753 | 2/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633852 | 1.00 | TRPV1 (0.47) | TRPV1HSD11B1RBP4GRM1HRH3 | |
| SCHEMBL1734703 | 0.76 | HSD11B1 (0.52) | TRPV1HSD11B1RBP4GRM1 | |
| SCHEMBL1734453 | 0.76 | HSD11B1 (0.52) | TRPV1HSD11B1RBP4GRM1 | |
| SCHEMBL1734455 | 0.76 | HSD11B1 (0.52) | TRPV1HSD11B1RBP4GRM1 | |
| SCHEMBL3632572 | 0.73 | HSD11B1 (0.46) | TRPV1HSD11B1RBP4HRH3 | |
| SCHEMBL4266990 | 0.73 | TRPV1 (0.69) | TRPV1HSD11B1RBP4GRM1 | |
| SCHEMBL3631891 | 0.71 | ALDH1A1 (0.39) | — | |
| SCHEMBL3632439 | 0.71 | HSD11B1 (0.43) | TRPV1HSD11B1RBP4HRH3 | |
| SCHEMBL3623860 | 0.70 | HSD11B1 (0.52) | TRPV1HSD11B1RBP4 | |
| SCHEMBL4262872 | 0.69 | TRPV1 (0.77) | TRPV1RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142533-A1 | IMIDAZOLIDINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | claimed |
| WO-2008119657-A1 | IMIDAZOLIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | WO | claimed |
| EP-2142533-A1 | IMIDAZOLIDINONE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119657-A1 | IMIDAZOLIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | WO | disclosed |