SCHEMBL3632871

SCHEMBL3632871

BrCCn1cc2ccccc2c1

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.34
CES1 P23141 1/20 0.34
CDK4 P11802 4/20 0.33
CCND1 P24385 4/20 0.33
CYP2A6 P11509 1/20 0.33
ALOX12 P18054 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
TRPA1 O75762 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4210095 0.86 CDK4 (0.33) CDK4CCND1CYP2A6ALOX12TDP1
SCHEMBL30179235 0.84 CDK4 (0.36) CDK4CCND1TDP1
SCHEMBL6426597 0.82 CDK4 (0.38) CDK4CCND1
SCHEMBL29351222 0.79 CYP2A6 (0.37) CDK4CCND1CYP2A6ALOX12TDP1
SCHEMBL377726 0.75 CDK4 (0.33) CDK4CCND1CYP2A6ALOX12ALDH1A1
SCHEMBL7004471 0.75 HTR2A (0.38) CDK4CCND1CYP2A6ALOX12ALDH1A1
SCHEMBL5728630 0.73 PTPN1 (0.37) ALDH1A1TSHR
SCHEMBL11801475 0.71 HEXA (0.42)
SCHEMBL10386587 0.69 CYP2A6 (0.37) CDK4CCND1CYP2A6ALOX12TDP1
SCHEMBL10412639 0.69 CYP2A6 (0.37) CYP2A6ALOX12ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2155735-A2 TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS ELI LILLY AND COMPANY (US) 2010-02-24 EP disclosed
WO-2008144222-A2 TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS ELI LILLY AND COMPANY (US) 2008-11-27 WO disclosed
US-4968705-A ANTIINFLAMMATORY AGENTS FOR RESPIRATORY SYSTEM DISORDERS ADIR ET CIE (FR) 1990-11-06 US disclosed