Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | CPA1 | P15085 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7634312 | 0.79 | KMO (0.50) | LMNAKMOALDH1A1 | |
| SCHEMBL5729887 | 0.77 | ALDH1A1 (0.44) | LMNAHPGDTSHRKMOMAPK1 | |
| SCHEMBL27801037 | 0.77 | LMNA (0.54) | LMNAHPGDTSHRKMOMAPK1 | |
| SCHEMBL3632871 | 0.73 | BCHE (0.34) | TSHRALDH1A1 | |
| SCHEMBL7365093 | 0.72 | FABP4 (0.51) | KMOMAPK1ALDH1A1HDAC3HDAC4 | |
| SCHEMBL608395 | 0.72 | LMNA (0.49) | LMNAHPGDMAPK1ALDH1A1MTNR1A | |
| SCHEMBL7633464 | 0.70 | FABP4 (0.53) | MAPK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29452030 | 0.69 | ALDH1A1 (0.54) | HPGDTSHRALDH1A1HDAC3HDAC4 | |
| SCHEMBL133129 | 0.69 | ALDH1A1 (0.54) | HPGDTSHRALDH1A1HDAC3HDAC4 | |
| SCHEMBL377726 | 0.69 | CDK4 (0.33) | HPGDMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644320-A1 | INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005009941-A1 | INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2005-02-03 | — | — | WO | disclosed |