Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3349351 | 0.82 | KDM4E (0.49) | ERN1MAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL639132 | 0.77 | KDM4E (0.47) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3343223 | 0.75 | NPC1 (0.49) | MAPTGAAALDH1A1KDM4EGFER | |
| SCHEMBL16378738 | 0.73 | MAPT (0.53) | ERN1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL640473 | 0.71 | GAA (0.56) | GAAALDH1A1KDM4EGFERMEN1 | |
| SCHEMBL3347321 | 0.71 | KDM4E (0.58) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL3342864 | 0.68 | CYP2D6 (0.54) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL638571 | 0.64 | GFER (0.51) | MAPTGAAALDH1A1KDM4EGFER | |
| SCHEMBL10211503 | 0.63 | L3MBTL1 (0.57) | MAPTSMN1; SMN2KDM4EKMT2ALMNA | |
| SCHEMBL3343847 | 0.63 | ALDH1A1 (0.58) | MAPTGAAALDH1A1KDM4EGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164486-A2 | USE OF 4-PHENYL-IMIDAZOLE-2-THIONES AS TYROSINASE INHIBITORS FOR PREPARING PHARMACEUTICAL OR COSMETIC COMPOSITIONS FOR TREATING OR PREVENTING PIGMENT DISORDERS | Galderma Research & Development (FR) | 2010-03-24 | — | — | EP | claimed |
| WO-2008152330-A2 | USE OF 4-PHENYL-IMIDAZOLE-2-THIONES AS TYROSINASE INHIBITORS FOR PREPARING PHARMACEUTICAL OR COSMETIC COMPOSITIONS FOR TREATING OR PREVENTING PIGMENT DISORDERS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-12-18 | — | — | WO | claimed |