Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630988 | 0.86 | MAPK14 (0.42) | MAPK14MAPK13RAF1PDGFRAMAPKAPK2 | |
| SCHEMBL3635641 | 0.73 | MAPK14 (0.39) | MAPK14MAPKAPK2MAPK11 | |
| SCHEMBL1889876 | 0.69 | MAPK14 (0.60) | MAPK14MAPK13RAF1PDGFRAMAPKAPK2 | |
| SCHEMBL1885642 | 0.61 | MAPK14 (0.82) | MAPK14MAPK13RAF1PDGFRAMAPKAPK2 | |
| SCHEMBL1882591 | 0.60 | MAPK14 (0.48) | MAPK14MAPKAPK2 | |
| SCHEMBL27888227 | 0.51 | OPRL1 (0.42) | KCNH2 | |
| SCHEMBL31532127 | 0.51 | CYP1A2 (0.47) | MAPK14 | |
| SCHEMBL11055943 | 0.50 | HCAR1 (0.41) | — | |
| SCHEMBL9919079 | 0.50 | PARG (0.41) | — | |
| SCHEMBL30885804 | 0.49 | GAA (0.46) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152706-A1 | PYRAZOLO-PYRIDINONE AND PYRAZOLO-PYRAZINONE COMPOUNDS AS P38 MODULATORS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | Amgen Inc. (US) | 2010-02-17 | — | — | EP | claimed |
| WO-2008136948-A1 | PYRAZOLO-PYRIDINONE AND PYRAZOLO-PYRAZINONE COMPOUNDS AS P38 MODULATORS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | AMGEN INC. (US) | 2008-11-13 | — | — | WO | claimed |