Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | STAT5A | P42229 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635641 | 0.88 | MAPK14 (0.39) | MAPK14MAPKAPK2MAPK11WEE1FGFR1 | |
| SCHEMBL3633577 | 0.86 | MAPK14 (0.34) | MAPK14PDGFRAMAPKAPK2MAPK13RAF1 | |
| SCHEMBL1885642 | 0.69 | MAPK14 (0.82) | MAPK14PDGFRAMAPKAPK2MAPK13RAF1 | |
| SCHEMBL1892898 | 0.61 | MAPK14 (0.64) | MAPK14PDGFRAMAPKAPK2MAPK13RAF1 | |
| SCHEMBL1887465 | 0.61 | MAPK14 (0.64) | MAPK14PDGFRAMAPKAPK2MAPK13RAF1 | |
| SCHEMBL16986316 | 0.56 | WEE1 (0.69) | MAPK14PDGFRAWEE1FGFR1ABL1 | |
| SCHEMBL5764396 | 0.54 | FGFR1 (1.00) | MAPK14PDGFRAWEE1FGFR1ABL1 | |
| SCHEMBL5116114 | 0.52 | MAPK14 (0.87) | MAPK14MAPK11 | |
| SCHEMBL5763591 | 0.52 | SRC (0.77) | MAPK14PDGFRAWEE1FGFR1ABL1 | |
| SCHEMBL13463624 | 0.51 | ROCK2 (0.51) | MAPK14MAPKAPK2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152706-A1 | PYRAZOLO-PYRIDINONE AND PYRAZOLO-PYRAZINONE COMPOUNDS AS P38 MODULATORS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | Amgen Inc. (US) | 2010-02-17 | — | — | EP | claimed |
| WO-2008136948-A1 | PYRAZOLO-PYRIDINONE AND PYRAZOLO-PYRAZINONE COMPOUNDS AS P38 MODULATORS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | AMGEN INC. (US) | 2008-11-13 | — | — | WO | claimed |