Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 5/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | CD74 | P04233 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632389 | 0.92 | MIF (0.47) | MIFBRAFCD74PKMPOLB | |
| SCHEMBL3633656 | 0.88 | MIF (0.63) | MIFCD74PKMPOLBMAPT | |
| SCHEMBL2540880 | 0.87 | MIF (0.49) | MIFCD74PKMPOLBMAPT | |
| SCHEMBL2542424 | 0.84 | MIF (0.48) | MIFCD74PKMPOLBMAPT | |
| SCHEMBL14563237 | 0.82 | MIF (0.60) | MIFCD74POLBMAPTSMN1; SMN2 | |
| SCHEMBL12266432 | 0.78 | MAPT (0.45) | MIFBRAFPKMPOLBMAPT | |
| SCHEMBL14563223 | 0.78 | MIF (0.70) | MIFCD74POLBMAPTALDH1A1 | |
| SCHEMBL12240999 | 0.78 | SIGMAR1 (0.44) | MIFPKMMAPTLMNAHSD17B10 | |
| SCHEMBL12266109 | 0.77 | PIK3CB (0.51) | MIFCD74PKMPOLBMAPT | |
| SCHEMBL12241002 | 0.77 | SIGMAR1 (0.45) | MIFPKMMAPTLMNAMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |
| EP-2150551-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008148449-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | WO | disclosed |