Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 6/20 | 0.47 |
| ▸ | CD74 | P04233 | 3/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CBX7 | O95931 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.43 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.43 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633664 | 0.92 | MIF (0.48) | MIFCD74BRAFPOLBPKM | |
| SCHEMBL3633656 | 0.87 | MIF (0.63) | MIFCD74POLBPKMTNIK | |
| SCHEMBL2542424 | 0.85 | MIF (0.48) | MIFCD74POLBPKMTNIK | |
| SCHEMBL2540880 | 0.84 | MIF (0.49) | MIFCD74POLBPKMSMN1; SMN2 | |
| SCHEMBL14563237 | 0.82 | MIF (0.60) | MIFCD74POLBTNIKSMN1; SMN2 | |
| SCHEMBL3629237 | 0.82 | TNIK (0.52) | MIFCD74BRAFPOLBTNIK | |
| SCHEMBL3629990 | 0.79 | IDO1 (0.52) | MIFCD74POLBTNIK | |
| SCHEMBL12266432 | 0.78 | MAPT (0.45) | MIFBRAFPOLBPKMMET | |
| SCHEMBL12240999 | 0.77 | SIGMAR1 (0.44) | MIFPKMSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL12266109 | 0.77 | PIK3CB (0.51) | MIFCD74POLBPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150530-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-02-10 | — | — | EP | claimed |
| WO-2008131947-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |