Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1141068 | 1.00 | KCNH2 (0.85) | KCNH2HRH3 | |
| Fumaric Acid SCHEMBL1141067 | 1.00 | KCNH2 (0.85) | KCNH2HRH3 | |
| Maleic Acid SCHEMBL1141066 | 1.00 | KCNH2 (0.85) | KCNH2HRH3 | |
| SCHEMBL1128120 | 0.92 | KCNH2 (1.00) | KCNH2HRH3 | |
| SCHEMBL1128396 | 0.92 | KCNH2 (1.00) | KCNH2HRH3 | |
| Hydrochloric Acid SCHEMBL1141464 | 0.92 | KCNH2 (0.98) | KCNH2HRH3 | |
| Hydrochloric Acid SCHEMBL1141460 | 0.92 | KCNH2 (0.98) | KCNH2HRH3 | |
| SCHEMBL1938186 | 0.87 | KCNH2 (1.00) | KCNH2HRH3 | |
| SCHEMBL1939700 | 0.87 | KCNH2 (1.00) | KCNH2HRH3 | |
| SCHEMBL1939411 | 0.87 | KCNH2 (1.00) | KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013151982-A1 | METHODS AND COMPOUNDS USEFUL IN TREATING PRURITUS, AND METHODS FOR IDENTIFYING SUCH COMPOUNDS | ARENA PHARMACEUTICALS, INC. (US) | 2013-10-10 | — | — | WO | disclosed |
| EP-2155668-A2 | CRYSTALLINE FORMS OF (R)-1-{2-Ý4'- (3-METHOXY-PROPANE-1- SULFONYL)-BIPHENYL-4-YL¨-ETHYL}-2-METHYL-PYRROLIDINE, AND COMPOSITIONS, AND METHODS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008153958-A2 | CRYSTALLINE FORMS OF (R)-1-{2-[4'- (3-METHOXY-PROPANE-1- SULFONYL)-BIPHENYL-4-YL]-ETHYL}-2-METHYL-PYRROLIDINE, AND COMPOSITIONS, AND METHODS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-12-18 | — | — | WO | disclosed |