Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790620 | 0.98 | TAAR1 (0.48) | TAAR1ALDH1A1TSHRNR4A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9834274 | 0.96 | TAAR1 (0.47) | TAAR1ALDH1A1TSHRNR4A2CYP3A4 | |
| SCHEMBL3784038 | 0.86 | ALDH1A1 (0.50) | TAAR1ALDH1A1TSHRNR4A2CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL14719474 | 0.85 | TAAR1 (0.56) | TAAR1ALDH1A1TSHRF2RL1DHFR | |
| Hydrochloric Acid SCHEMBL9832823 | 0.85 | ALDH1A1 (0.48) | TAAR1ALDH1A1TSHRNR4A2CYP3A4 | |
| SCHEMBL9174929 | 0.83 | TAAR1 (0.58) | TAAR1ALDH1A1TSHRF2RL1DHFR | |
| SCHEMBL3697918 | 0.83 | CYP3A4 (0.43) | ALDH1A1TSHRCYP3A4PIK3CAGAA | |
| SCHEMBL3791097 | 0.81 | ALDH1A1 (0.52) | TAAR1ALDH1A1TSHRNR4A2CYP3A4 | |
| SCHEMBL29701394 | 0.81 | ALDH1A1 (0.52) | TAAR1ALDH1A1TSHRNR4A2CYP3A4 | |
| SCHEMBL4640020 | 0.78 | TAAR1 (0.48) | TAAR1ALDH1A1TSHRNR4A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146969-A1 | NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Novartis Ag (CH) | 2010-01-27 | — | — | EP | disclosed |
| US-20090105266-A1 | Organic compounds | NOVARTIS AG (CH) | 2009-04-23 | — | — | US | disclosed |
| WO-2008128968-A1 | NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | NOVARTIS AG (CH) | 2008-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105266-A1 | Organic compounds | SLCO2B1, SLCO1B1, SLCO1B3 | TAAR1 3209/4885ALDH1A1 45/4885TSHR 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.