Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.56 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.44 |
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9174929 | 0.97 | TAAR1 (0.58) | TAAR1F2RL1CFTRAKR1B1SMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL3633715 | 0.85 | TAAR1 (0.47) | TAAR1F2RL1CFTRAKR1B1SMN1; SMN2 | |
| SCHEMBL18568047 | 0.84 | TAAR1 (0.45) | TAAR1F2RL1CFTRAKR1B1SMN1; SMN2 | |
| SCHEMBL11507567 | 0.84 | TAAR1 (0.45) | TAAR1F2RL1CFTRAKR1B1SMN1; SMN2 | |
| SCHEMBL11910714 | 0.83 | TAAR1 (0.54) | TAAR1CFTRAKR1B1SMN1; SMN2MEN1 | |
| SCHEMBL13228082 | 0.82 | TAAR1 (0.68) | TAAR1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL14047772 | 0.82 | TAAR1 (0.43) | TAAR1F2RL1CFTRAKR1B1SMN1; SMN2 | |
| SCHEMBL10636626 | 0.82 | TSHR (0.46) | TAAR1F2RL1CFTRAKR1B1SMN1; SMN2 | |
| SCHEMBL3790620 | 0.82 | TAAR1 (0.48) | TAAR1F2RL1CFTRAKR1B1SMN1; SMN2 | |
| SCHEMBL6826937 | 0.82 | ALDH1A1 (0.49) | TAAR1F2RL1CFTRAKR1B1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249147-B2 | Tyrosine kinase inhibitors | CHEMBRIDGE CORPORATION (US) | 2016-02-02 | — | — | US | disclosed |
| EP-2966076-A1 | NOVEL TYROSINE KINASE INHIBITORS | ChemBridge Corporation (US) | 2016-01-13 | — | — | EP | disclosed |
| US-20150011539-A1 | NOVEL TYROSINE KINASE INHIBITORS | CHEMBRIDGE COPRPORATION | 2015-01-08 | — | — | US | disclosed |
| US-8815906-B2 | Tyrosine kinase inhibitors | CHEMBRIDGE CORPORATION (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130053376-A1 | NOVEL TYROSINE KINASE INHIBITORS | CHEMBRIDGE COPRPORATION | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011539-A1 | NOVEL TYROSINE KINASE INHIBITORS | ABL1, RET, TTBK1 | TAAR1 1120/4885F2RL1 2643/4885CFTR 3987/4885 |
| US-20130053376-A1 | NOVEL TYROSINE KINASE INHIBITORS | ABL1, RET, TTBK1 | TAAR1 1120/4885F2RL1 2643/4885CFTR 3987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.