Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | SCN2B | O60939 | 3/20 | 0.35 |
| ▸ | SCN1B | Q07699 | 3/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3626683 | 0.88 | NOTUM (0.42) | NOTUMALDH1A1L3MBTL1ABCB1GRM1 | |
| SCHEMBL3633919 | 0.87 | MEN1 (0.45) | NOTUMALDH1A1ABCB1MEN1KMT2A | |
| SCHEMBL3633608 | 0.86 | ABCB1 (0.53) | NOTUML3MBTL1ABCB1PTGS2MEN1 | |
| SCHEMBL3632701 | 0.85 | KDM4E (0.47) | NOTUMALDH1A1TSHRMGLLMEN1 | |
| SCHEMBL3633358 | 0.83 | NOTUM (0.44) | NOTUMALDH1A1L3MBTL1ABCB1SCN2B | |
| SCHEMBL3631491 | 0.81 | ABCB1 (0.49) | NOTUMALDH1A1L3MBTL1ABCB1MEN1 | |
| SCHEMBL4283426 | 0.81 | GRM1 (0.40) | ALDH1A1GRM1TUBB4ATUBBTUBA3C | |
| SCHEMBL3631359 | 0.81 | NOTUM (0.45) | NOTUMPTGS2SCN2BSCN1BSCN5A | |
| SCHEMBL3633448 | 0.80 | NOTUM (0.43) | NOTUMALDH1A1ABCB1 | |
| SCHEMBL3631115 | 0.79 | CA12 (0.43) | NOTUMALDH1A1ABCB1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150534-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008131779-A1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2008-11-06 | — | — | WO | disclosed |