Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 5/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18708221 | 0.87 | TRPC6 (0.49) | TRPC6PDE4BCNR2PDE4APDE4C | |
| SCHEMBL88281 | 0.87 | TRPC6 (0.49) | TRPC6PDE4BCNR2PDE4APDE4C | |
| SCHEMBL71158 | 0.86 | TRPC6 (0.48) | TRPC6PDE4BCNR2PDE4APDE4C | |
| SCHEMBL21045798 | 0.81 | TRPC6 (0.55) | TRPC6CNR2 | |
| SCHEMBL15757242 | 0.81 | PDE4B (0.41) | TRPC6PDE4BPDE4APDE4CPDE4D | |
| Potassium Ion SCHEMBL15757775 | 0.80 | TRPC6 (0.44) | TRPC6PDE4BCNR2PDE4APDE4C | |
| SCHEMBL21045633 | 0.80 | TRPC6 (0.54) | TRPC6CNR2 | |
| SCHEMBL30439691 | 0.80 | TRPC6 (0.54) | TRPC6CNR2 | |
| SCHEMBL15757180 | 0.79 | TRPC6 (0.48) | TRPC6PDE4BCNR2PDE4D | |
| SCHEMBL4269812 | 0.78 | PDE4B (0.62) | PDE4BPARP15PARP10PDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150253-A2 | USE OF 4-CYCLOPROPYLMETHOXY-<I>N</I>-(3,5-DICHLORO-1-OXIDOPYRIDIN-4-YL)-5-(METHOXY)PYRIDINE-2-CARBOXAMIDE FOR THE TREATMENT OF SPINAL CORD TRAUMAS | Sanofi-Aventis (FR) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008145840-A2 | USE OF 4-CYCLOPROPYLMETHOXY-N-(3,5-DICHLORO-1-OXIDOPYRIDIN-4-YL)-5-(METHOXY)PYRIDINE-2-CARBOXAMIDE FOR THE TREATMENT OF SPINAL CORD TRAUMAS | SANOFI-AVENTIS (FR) | 2008-12-04 | — | — | WO | disclosed |