Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | AHR | P35869 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3337540 | 0.95 | POLB (0.65) | POLBGAAMAPTRECQLRAB9A | |
| SCHEMBL2974551 | 0.78 | CYP1A2 (0.62) | POLBGAAMAPTRAB9AKDM4E | |
| SCHEMBL3340353 | 0.77 | S1PR4 (0.54) | MAPTRAB9AKMT2AMEN1PDE4D | |
| SCHEMBL30993906 | 0.77 | S1PR4 (0.54) | MAPTRAB9AKMT2AMEN1PDE4D | |
| SCHEMBL13576585 | 0.76 | PDE4D (0.76) | POLBMAPTRAB9AKDM4EKMT2A | |
| SCHEMBL3338770 | 0.76 | TAS1R3 (0.53) | POLBGAARAB9AKDM4EKMT2A | |
| SCHEMBL16681360 | 0.76 | KMT2A (0.76) | POLBMAPTRAB9AKDM4EHSP90AA1 | |
| SCHEMBL8970331 | 0.76 | MAPT (0.65) | POLBGAAMAPTRECQLRAB9A | |
| SCHEMBL1017706 | 0.75 | NPC1 (0.64) | GAAMAPTRAB9AKDM4EKMT2A | |
| SCHEMBL12368121 | 0.74 | SIRT2 (0.76) | MAPTRAB9AKMT2AMEN1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155194-A1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008124610-A1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-10-16 | — | — | WO | disclosed |