SCHEMBL8970331

SCHEMBL8970331

COc1ccccc1NC(=O)c1cccc(Br)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.65
RAB9A P51151 5/20 0.65
NPC1 O15118 4/20 0.65
SIRT2 Q8IXJ6 1/20 0.63
POLB P06746 2/20 0.62
GAA P10253 1/20 0.62
RECQL P46063 1/20 0.62
KDM4E B2RXH2 2/20 0.60
HSP90AA1 P07900 1/20 0.60
HDAC1 Q13547 1/20 0.59
HDAC8 Q9BY41 1/20 0.59
HDAC6 Q9UBN7 1/20 0.59
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
MCL1 Q07820 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
PABPC1 P11940 1/20 0.57
APOBEC3A P31941 1/20 0.57
EIF4H Q15056 1/20 0.57
APOBEC3G Q9HC16 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27876288 0.86 RAB9A (0.70) MAPTRAB9ANPC1POLBGAA
SCHEMBL6798428 0.84 MEN1 (0.83) RAB9ANPC1SIRT2POLBGAA
SCHEMBL28241911 0.84 MEN1 (0.74) MAPTRAB9ANPC1SIRT2GAA
SCHEMBL28579272 0.84 MAPT (0.63) MAPTRAB9ANPC1GAAMEN1
SCHEMBL12189597 0.83 MAPT (0.66) MAPTMEN1KMT2ANPSR1
SCHEMBL29989592 0.83 RAB9A (0.77) MAPTRAB9ANPC1KDM4EHDAC1
SCHEMBL527994 0.83 RAB9A (0.77) MAPTRAB9ANPC1KDM4EHDAC1
SCHEMBL16681360 0.83 KMT2A (0.76) MAPTRAB9ANPC1SIRT2POLB
SCHEMBL10144734 0.83 AKR1C2 (0.59) RAB9ANPC1POLBGAAMEN1
SCHEMBL2624524 0.81 AKR1C2 (0.75) MAPTRAB9ANPC1GAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP claimed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US claimed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP claimed
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP disclosed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US disclosed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP disclosed