Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636351 | 0.89 | KCNH2 (0.40) | MAOAMAOBKCNH2GRM2SIGMAR1 | |
| SCHEMBL3636533 | 0.87 | DRD4 (0.40) | KCNH2GRM2SIGMAR1 | |
| SCHEMBL3633671 | 0.86 | MAOA (0.37) | MAOAMAOBKCNH2GRM2SIGMAR1 | |
| SCHEMBL3629842 | 0.84 | GRM2 (0.35) | MAOAMAOBKCNH2GRM2MTNR1B | |
| SCHEMBL3633094 | 0.84 | KCNH2 (0.38) | MAOAMAOBKCNH2GRM2PDE3B | |
| SCHEMBL1223131 | 0.80 | SIGMAR1 (0.43) | SIGMAR1MTNR1B | |
| SCHEMBL1223130 | 0.80 | SIGMAR1 (0.43) | SIGMAR1MTNR1B | |
| SCHEMBL1224202 | 0.80 | SIGMAR1 (0.43) | SIGMAR1MTNR1B | |
| SCHEMBL1224343 | 0.79 | KCNH2 (0.40) | MAOAMAOBKCNH2GRM2MTNR1B | |
| SCHEMBL1224345 | 0.79 | KCNH2 (0.40) | MAOAMAOBKCNH2GRM2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144910-A2 | OXAZOLIDINONE ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008126034-A2 | OXAZOLIDINONE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-23 | — | — | WO | disclosed |