Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 6/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31635698 | 0.84 | ACACB (0.45) | ACACBESR1ESR2MEN1KMT2A | |
| SCHEMBL27986499 | 0.83 | MME (0.45) | ACACBMMEEPHX1MEN1NPC1 | |
| SCHEMBL4283538 | 0.82 | SLC6A2 (0.47) | ACACBESR1ESR2MEN1NPC1 | |
| SCHEMBL3713994 | 0.82 | ALPI (0.53) | NPC1RAB9ACYP1A2 | |
| SCHEMBL27807869 | 0.82 | MME (0.51) | MMEMEN1NPC1RAB9AKMT2A | |
| SCHEMBL12459110 | 0.82 | MME (0.53) | ACACBMMEMEN1NPC1RAB9A | |
| SCHEMBL1867578 | 0.82 | ACACB (0.49) | ACACBMMEEPHX1ESR1ESR2 | |
| SCHEMBL19369764 | 0.80 | ACACB (0.47) | ACACBMMEEPHX1ESR1ESR2 | |
| SCHEMBL14559931 | 0.80 | SLC7A5 (0.48) | ACACBMMEEPHX1ESR1ESR2 | |
| SCHEMBL14355742 | 0.80 | SLC7A5 (0.48) | ACACBMMEEPHX1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152271-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | Janssen Pharmaceutica, N.V. (BE) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008148840-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-11 | — | — | WO | disclosed |