SCHEMBL4283538

SCHEMBL4283538

CC(=O)C(Br)Cc1ccc(Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.47
SLC6A3 Q01959 1/20 0.47
ACACB O00763 1/20 0.46
SLC6A4 P31645 1/20 0.45
PPARG P37231 6/20 0.45
PPARA Q07869 5/20 0.45
BRD4 O60885 1/20 0.44
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
HTT P42858 2/20 0.42
LMNA P02545 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
RAB9A P51151 2/20 0.40
ALDH1A1 P00352 1/20 0.40
NPC1 O15118 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27700293 0.84 SLC6A4 (0.48) SLC6A2SLC6A3ACACBSLC6A4PPARG
SCHEMBL5743776 0.82 PPARG (0.54) SLC6A2SLC6A3SLC6A4PPARGPPARA
SCHEMBL31635698 0.82 ACACB (0.45) ACACBPPARGPPARAMEN1KMT2A
SCHEMBL3634087 0.82 ACACB (0.47) ACACBPPARGPPARAMEN1KMT2A
SCHEMBL3773871 0.82 SLC6A2 (0.52) SLC6A2SLC6A3ACACBSLC6A4PPARG
SCHEMBL15451590 0.80 NOS2 (0.46) SLC6A2SLC6A3ACACBPPARGPPARA
SCHEMBL11165041 0.80 SLC6A2 (0.43) SLC6A2SLC6A3ACACBSLC6A4PPARG
SCHEMBL3713994 0.80 ALPI (0.53) LMNARAB9AALDH1A1NPC1
SCHEMBL15454448 0.80 SLC6A2 (0.50) SLC6A2SLC6A3ACACBSLC6A4PPARG
SCHEMBL19369765 0.78 SLC6A2 (0.48) SLC6A2SLC6A3ACACBSLC6A4PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009150196-A1 N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE SMITHKLINE BEECHAM CORPORATION (US) 2009-12-17 WO disclosed
WO-2009150196-A1 N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE SMITHKLINE BEECHAM CORPORATION (US) 2009-12-17 WO disclosed
EP-0770073-A1 ANTI-HELICOBACTER HETEROCYCLIC DERIVATIVES OF AZOLONES JANSSEN PHARMACEUTICA N.V. (BE) 1997-05-02 EP disclosed
EP-0754180-A1 ANTI-HELICOBACTER ESTER AND CARBAMATE DERIVATIVES OF AZOLONES JANSSEN PHARMACEUTICA N.V. (BE) 1997-01-22 EP disclosed
WO-1996001821-A1 ANTI-HELICOBACTER HETEROCYCLIC DERIVATIVES OF AZOLONES JANSSEN PHARMACEUTICA N.V. (BE) 1996-01-25 WO disclosed
EP-0684821-A1 SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER JANSSEN PHARMACEUTICA N.V. (BE) 1995-12-06 EP disclosed
WO-1995027704-A1 ANTI-HELICOBACTER ESTER AND CARBAMATE DERIVATIVES OF AZOLONES JANSSEN PHARMACEUTICA N.V. (BE) 1995-10-19 WO disclosed
WO-1994018978-A1 SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER JANSSEN PHARMACEUTICA N.V. (BE) 1994-09-01 WO disclosed
EP-0020173-B1 IMIDAZOLE GUANIDINES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM MERCK & CO. INC. (US) 1983-02-09 EP disclosed
EP-0020173-A1 Imidazole guanidines, their preparation and compositions containing them MERCK & CO. INC. (US) 1980-12-10 EP disclosed
US-4220654-A Cyclic imidazole cyanoguanidines MERCK & CO., INC. (US) 1980-09-02 US disclosed