Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636151 | 0.85 | MAPT (0.41) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2324136 | 0.85 | NPSR1 (0.55) | MAPTSMN1; SMN2ALDH1A1MAPK1MEN1 | |
| SCHEMBL1040135 | 0.84 | MAPT (0.46) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2331462 | 0.81 | CSNK2A1 (0.50) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL3636996 | 0.78 | DHODH (0.59) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL1037436 | 0.78 | PSEN1 (0.58) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3635538 | 0.78 | PLA2G7 (0.37) | MAPTSMN1; SMN2ALDH1A1MAPK1MEN1 | |
| SCHEMBL2322931 | 0.78 | PSEN1 (0.45) | MAPTSMN1; SMN2ALDH1A1MAPK1MEN1 | |
| SCHEMBL3636545 | 0.77 | PLA2G7 (0.37) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL3636644 | 0.77 | PLA2G7 (0.37) | MAPTSMN1; SMN2ALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |