Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634147 | 0.85 | MAPT (0.56) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL1040135 | 0.84 | MAPT (0.46) | MAPTGAAMEN1KMT2ACYP1A2 | |
| SCHEMBL3637440 | 0.81 | TP53 (0.40) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL3636644 | 0.80 | PLA2G7 (0.37) | MAPTGAAMEN1KMT2ACYP1A2 | |
| SCHEMBL1040769 | 0.80 | PSEN1 (0.54) | CYP3A4 | |
| SCHEMBL3634246 | 0.79 | PLA2G7 (0.36) | MAPTGAAMEN1KMT2ACYP1A2 | |
| SCHEMBL2324136 | 0.78 | NPSR1 (0.55) | MAPTGAAMEN1KMT2ACYP1A2 | |
| SCHEMBL2331462 | 0.78 | CSNK2A1 (0.50) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL3636545 | 0.77 | PLA2G7 (0.37) | MAPTGAAMEN1KMT2ACYP1A2 | |
| SCHEMBL3632982 | 0.76 | PLA2G7 (0.38) | MAPTGAAMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |