Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12124925 | 0.84 | TAS1R3 (0.53) | TAS1R3TAS1R1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL12124934 | 0.84 | KMT2A (0.60) | TAS1R3TAS1R1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL13702374 | 0.78 | KMT2A (0.69) | ALDH1A1LMNASMN1; SMN2SMPD1NPC1 | |
| SCHEMBL14969346 | 0.77 | SMN1; SMN2 (0.65) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL17662852 | 0.77 | KMT2A (0.61) | ALDH1A1LMNASMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL24500604 | 0.77 | SMPD1 (0.70) | ALDH1A1SMPD1PLK1 | |
| SCHEMBL3850447 | 0.75 | NPC1 (0.70) | ALDH1A1LMNASMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL30416225 | 0.75 | NPC1 (0.70) | ALDH1A1LMNASMN1; SMN2HDAC8HDAC6 | |
| SCHEMBL13702279 | 0.75 | SMN1; SMN2 (0.54) | TAS1R3TAS1R1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL31194774 | 0.74 | SMPD1 (0.80) | SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150526-A2 | N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE | High Point Pharmaceuticals, LLC (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008101914-A2 | N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE | HIGH POINT PHARMACEUTICALS, LLC (GB) | 2008-08-28 | — | — | WO | disclosed |