Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680646 | 0.84 | HSD17B10 (0.40) | MRGPRX4L3MBTL1POLBGAAMEN1 | |
| SCHEMBL680059 | 0.82 | SCN9A (0.56) | SCN9A | |
| SCHEMBL3388103 | 0.76 | TSHR (0.53) | MRGPRX4ALDH1A1L3MBTL1POLBGAA | |
| SCHEMBL29488334 | 0.76 | TSHR (0.53) | MRGPRX4ALDH1A1L3MBTL1POLBGAA | |
| SCHEMBL30843194 | 0.76 | TSHR (0.52) | MRGPRX4ALDH1A1L3MBTL1POLBGAA | |
| SCHEMBL15094323 | 0.75 | TTR (0.54) | MRGPRX4ALDH1A1L3MBTL1POLBGAA | |
| SCHEMBL30843180 | 0.75 | MAPT (0.39) | MRGPRX4ALDH1A1L3MBTL1POLBMEN1 | |
| SCHEMBL15094293 | 0.72 | TSHR (0.47) | MRGPRX4TTRMEN1MAPTKMT2A | |
| SCHEMBL71552 | 0.71 | ALDH1A1 (0.44) | ALDH1A1KMT2A | |
| SCHEMBL365555 | 0.71 | SLC6A4 (0.44) | MRGPRX4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007883-A1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |