Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053158 | 0.79 | SLC6A2 (0.45) | TSHRSCN9AMRGPRX4HTR1ASLC6A2 | |
| SCHEMBL30996881 | 0.79 | TSHR (0.61) | TSHRMRGPRX4MAPTKMT2A | |
| SCHEMBL15059548 | 0.76 | CXCL8 (0.44) | — | |
| SCHEMBL365555 | 0.76 | SLC6A4 (0.44) | SCN9AMRGPRX4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15094056 | 0.75 | SCN9A (0.55) | SCN9A | |
| SCHEMBL8348157 | 0.73 | ALDH1A1 (0.47) | MRGPRX4MEN1TTRMAPTKMT2A | |
| SCHEMBL28053101 | 0.73 | MEN1 (0.50) | HTR1ASLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL17244918 | 0.72 | SCN9A (0.51) | SCN9AMAPT | |
| SCHEMBL366037 | 0.72 | SCN9A (0.67) | SCN9A | |
| SCHEMBL363464 | 0.72 | MRGPRX4 (0.48) | TSHRSCN9AMRGPRX4MEN1TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2800740-A1 | N-AMINOSULFONYL BENZAMIDES | Pfizer Limited (GB) | 2014-11-12 | — | — | EP | disclosed |
| WO-2013102826-A1 | N-AMINOSULFONYL BENZAMIDES | PFIZER LIMITED (GB) | 2013-07-11 | — | — | WO | disclosed |