SCHEMBL3634770

SCHEMBL3634770

COc1ncc(Cl)cc1Br

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.46
LMNA P02545 1/20 0.46
TSHR P16473 1/20 0.46
APEX1 P27695 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
PLAU P00749 1/20 0.42
S100A9 P06702 3/20 0.41
MAPK1 P28482 1/20 0.40
CCR4 P51679 6/20 0.37
AMY1A P0DUB6 1/20 0.35
MAPT P10636 1/20 0.33
CASP1 P29466 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2005246 0.80 PLAU (0.40) CYP2C9LMNATSHRAPEX1SMN1; SMN2
SCHEMBL26693926 0.79 PLAU (0.39) CYP2C9LMNATSHRAPEX1SMN1; SMN2
SCHEMBL29837826 0.79 PLAU (0.39) CYP2C9LMNATSHRAPEX1SMN1; SMN2
SCHEMBL7055864 0.78 SMN1; SMN2 (0.64) CYP2C9LMNATSHRAPEX1SMN1; SMN2
SCHEMBL2655524 0.78 MAPT (0.39) S100A9MAPTCASP1
SCHEMBL1882789 0.78 HTT (0.46) CYP2C9SMN1; SMN2S100A9MAPTCASP1
SCHEMBL17450942 0.78 MAPT (0.45) SMN1; SMN2CCR4MAPTCASP1
SCHEMBL29102860 0.77 S100A9 (0.37) S100A9MAPTCASP1
SCHEMBL1845695 0.77 SLC13A5 (0.37) CYP2C9LMNASMN1; SMN2S100A9MAPK1
SCHEMBL6954046 0.77 SMN1; SMN2 (0.47) CYP2C9LMNATSHRAPEX1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 184 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON INC (US) 2026-03-12 US disclosed
US-12509474-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2025-12-30 US disclosed
EP-4638438-A1 ALPHA4 BETA7 INTEGRIN ANTAGONISTS AND USES THEREOF Xinthera, Inc. (US) 2025-10-29 EP disclosed
EP-4629985-A1 TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN Poseidon Innovation 1, Inc. (US) 2025-10-15 EP disclosed
EP-4629986-A1 TREATMENT OF GRAFT-VERSUS-HOST DISEASE WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN Poseidon Innovation 1, Inc. (US) 2025-10-15 EP disclosed
EP-4629987-A1 TREATMENT OF MYELOPROLIFERATIVE DISEASES AND DISORDERS WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN Poseidon Innovation 1, Inc. (US) 2025-10-15 EP disclosed
US-20250179059-A1 ANTICANCER COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-06-05 US disclosed
WO-2025078654-A1 ANTIBACTERIAL COMPOUNDS VEIRULENCE LTD (GB) 2025-04-17 WO disclosed
CN-119661503-A 4-Ethynyl pyridine derivatives as GCN2 inhibitors IP2IPO创新有限公司 2025-03-21 CN disclosed
CN-116113629-B 4-Ethynyl pyridine derivatives as GCN2 inhibitors IP2IPO创新有限公司 2024-12-31 CN disclosed
US-20060173006-A1 Compounds for inflammation and immune-related uses SYNTA PHARMACEUTICALS CORP. (US) 2006-08-03 US disclosed
EP-1660428-A1 PPAR MODULATORS ELI LILLY AND COMPANY (US) 2006-05-31 EP disclosed
WO-2005019151-A1 PPAR MODULATORS ELI LILLY AND COMPANY (US) 2005-03-03 WO disclosed
US-5681840-A ANTIDOPAMINERGIC AGENTS ZENECA LIMITED (GB) 1997-10-28 US disclosed
EP-0533344-B1 Methanoanthracenes as dopamine antagonists ZENECA LTD (GB) 1996-10-16 EP disclosed
US-5512575-A ANTISEROTONINE AGENT ZENECA LIMITED (GB) 1996-04-30 US disclosed
EP-0533344-A1 Methanoanthracenes as dopamine antagonists ZENECA LIMITED (GB) 1993-03-24 EP disclosed
EP-0178633-B1 2-phenylpyrano[2,3-b]pyridines MERRELL DOW PHARMACEUTICALS INC. (US) 1992-01-08 EP disclosed
US-4588733-A 2-phenylpyrano[2,3-b]pyridines and their use in inhibiting viruses MERRELL DOW PHARMACEUTICALS INC. (US) 1986-05-13 US disclosed
EP-0178633-A2 2-phenylpyrano[2,3-b]pyridines MERRELL DOW PHARMACEUTICALS INC. (US) 1986-04-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179059-A1 ANTICANCER COMPOUNDS BET1, BRD4, BICRA CYP2C9 4141/4885LMNA 4337/4885TSHR 4508/4885
US-12509474-B2 Inhibitors of complement factors and uses thereof SSB, UACA, CFH CYP2C9 3575/4885LMNA 1204/4885TSHR 437/4885
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFH, CFB, C5 CYP2C9 2095/4885LMNA 2986/4885TSHR 204/4885
US-20060173006-A1 Compounds for inflammation and immune-related uses CXCL8, CCR8, CXCR2 CYP2C9 189/4885LMNA 3080/4885TSHR 2510/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.