Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.42 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636994 | 0.85 | MAPK8 (0.47) | MAPK8MAPK9GPR17MAPK10TNKS2 | |
| SCHEMBL3938675 | 0.81 | HSD17B10 (0.47) | MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL22162673 | 0.77 | GPR17 (0.53) | GPR17TNKS2NR4A2 | |
| Hydrochloric Acid SCHEMBL2488114 | 0.74 | KCNH2 (0.42) | GPR17TNKS2NR4A2 | |
| SCHEMBL3634689 | 0.72 | MAPK8 (0.42) | MAPK8MAPK9MAPK10MEN1ALDH1A1 | |
| SCHEMBL3940003 | 0.72 | MAPK8 (0.52) | MAPK8MAPK9MAPK10RAB9AMAPT | |
| SCHEMBL3631272 | 0.72 | MAPK8 (0.44) | MAPK8MAPK9MAPK10MEN1ALDH1A1 | |
| SCHEMBL14604432 | 0.72 | GPR17 (0.56) | GPR17IMPDH2EGFR | |
| SCHEMBL3634381 | 0.71 | MAPK8 (0.53) | MAPK8MAPK9MAPK10TNKS2MAPT | |
| SCHEMBL3659426 | 0.70 | KDM4E (0.60) | GPR17RAB9AMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |