Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3631272 | 0.95 | MAPK8 (0.44) | MAPK8MAPK9MEN1KMT2AMAPK10 | |
| SCHEMBL3940003 | 0.91 | MAPK8 (0.52) | MAPK8MAPK9MAPK10LMNA | |
| SCHEMBL3634026 | 0.90 | MAPK8 (0.44) | MAPK8MAPK9MEN1KMT2A | |
| SCHEMBL3634381 | 0.89 | MAPK8 (0.53) | MAPK8MAPK9MEN1KMT2AAR | |
| SCHEMBL3635595 | 0.89 | MAPK8 (0.40) | MAPK8MAPK9MEN1KMT2AALDH1A1 | |
| SCHEMBL3945638 | 0.87 | MAPK8 (0.39) | MAPK8MAPK9MEN1KMT2AMAPK10 | |
| SCHEMBL3636491 | 0.87 | TP53 (0.40) | MAPK8MAPK9ALDH1A1USP2TSHR | |
| SCHEMBL14604229 | 0.87 | MAPK8 (0.49) | MAPK8 | |
| SCHEMBL3633153 | 0.86 | MAPK8 (0.41) | MAPK8MAPK9MEN1KMT2AMAPK10 | |
| SCHEMBL3938366 | 0.86 | MAPK8 (0.52) | MAPK8MAPK9MEN1KMT2AMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694480-A1 | ADAMANTYL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-02-12 | — | — | EP | disclosed |
| WO-2012136684-A1 | ADAMANTYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-11 | — | — | WO | disclosed |
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |