Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 11/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.53 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940003 | 0.91 | MAPK8 (0.52) | MAPK8MAPK9MAPK10LMNAMAPT | |
| SCHEMBL3634689 | 0.89 | MAPK8 (0.42) | MAPK8MAPK9MAPK10LMNAAR | |
| SCHEMBL3631272 | 0.89 | MAPK8 (0.44) | MAPK8MAPK9MAPK10LMNAMEN1 | |
| SCHEMBL3638919 | 0.85 | MAPK8 (0.43) | MAPK8MAPK9MAPK10MAPTSMN1; SMN2 | |
| SCHEMBL3938366 | 0.85 | MAPK8 (0.52) | MAPK8MAPK9MAPK10HPGDSMN1; SMN2 | |
| SCHEMBL3945638 | 0.84 | MAPK8 (0.39) | MAPK8MAPK9MAPK10MEN1KMT2A | |
| SCHEMBL3939176 | 0.84 | IKBKB (0.40) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14604210 | 0.84 | MAPK8 (0.51) | MAPK8 | |
| SCHEMBL14604229 | 0.84 | MAPK8 (0.49) | MAPK8 | |
| SCHEMBL14604008 | 0.84 | MAPK8 (0.48) | MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2009015917-A2 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |