Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.37 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633741 | 0.90 | PLA2G7 (0.37) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL3633324 | 0.85 | CCNT1 (0.41) | MAPTCCNT1CDK9ALDH1A1KMT2A | |
| SCHEMBL3637440 | 0.84 | TP53 (0.40) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL3636545 | 0.81 | PLA2G7 (0.37) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL3636644 | 0.81 | PLA2G7 (0.37) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL3634246 | 0.81 | PLA2G7 (0.36) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL3632982 | 0.80 | PLA2G7 (0.38) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL3637441 | 0.79 | PLA2G7 (0.39) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL3636568 | 0.79 | PLA2G7 (0.34) | MAPTKMT2AMEN1PLA2G7MAPK1 | |
| SCHEMBL1040135 | 0.78 | MAPT (0.46) | MAPTALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |