Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636479 | 0.86 | IMPDH2 (0.35) | PLA2G7MAPTMEN1KMT2AIMPDH2 | |
| SCHEMBL3640999 | 0.80 | CYP1B1 (0.53) | MAPTMEN1KMT2AGAANPC1 | |
| SCHEMBL3634963 | 0.79 | MAPT (0.40) | PLA2G7MAPTMEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL3635538 | 0.79 | PLA2G7 (0.37) | PLA2G7MAPTMEN1KMT2AGAA | |
| SCHEMBL3638760 | 0.79 | PSEN1 (0.48) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL1040135 | 0.78 | MAPT (0.46) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL3633741 | 0.78 | PLA2G7 (0.37) | PLA2G7MAPTMEN1KMT2AGAA | |
| SCHEMBL3636568 | 0.78 | PLA2G7 (0.34) | PLA2G7MAPTMEN1KMT2ARAB9A | |
| SCHEMBL3633324 | 0.78 | CCNT1 (0.41) | PLA2G7MAPTMEN1KMT2ANPC1 | |
| SCHEMBL3637440 | 0.77 | TP53 (0.40) | PLA2G7MAPTMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |