Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633670 | 0.89 | PTGES (0.39) | PTGES | |
| SCHEMBL3629880 | 0.87 | PTGES (0.39) | PTGES | |
| SCHEMBL4657991 | 0.86 | KDM4E (0.40) | PTGS2 | |
| SCHEMBL4658311 | 0.86 | KDM4E (0.52) | PTGS2 | |
| SCHEMBL4657739 | 0.85 | KDM4E (0.53) | — | |
| SCHEMBL4657891 | 0.85 | KDM4E (0.39) | — | |
| SCHEMBL4657944 | 0.84 | KDM4E (0.40) | — | |
| SCHEMBL4659144 | 0.81 | SDHB (0.36) | PTGS2 | |
| SCHEMBL4659091 | 0.81 | IDO1 (0.46) | — | |
| SCHEMBL4658948 | 0.80 | PDE4D (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154954-A1 | METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF | Sanford-Burnham Medical Research Institute (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191630-A1 | METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-12-17 | — | — | WO | disclosed |
| EP-2142527-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008119689-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | WO | disclosed |