Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | PRF1 | P14222 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632905 | 0.89 | PIK3CG (0.49) | PIK3CAPIK3CGPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL3087904 | 0.89 | PIK3CG (0.42) | PIK3CAPIK3CGPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL13706388 | 0.88 | PIK3CA (0.43) | PIK3CAPIK3CGPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL3091985 | 0.82 | PIK3CG (0.47) | PIK3CAPIK3CGPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL3083436 | 0.79 | PIK3CB (0.48) | PIK3CAPIK3CGPIK3CBMTORPRF1 | |
| SCHEMBL3097990 | 0.77 | PIK3CG (0.48) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL3078390 | 0.77 | CKS1B (0.51) | PIK3CAPIK3CGPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL3091718 | 0.77 | PIK3CA (0.48) | PIK3CAPIK3CGPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL3633883 | 0.76 | PIK3CB (0.67) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL3633859 | 0.76 | SCN9A (0.40) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150255-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | Smithkline Beecham Corporation (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008141065-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-20 | — | — | WO | disclosed |