Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3085473 | 0.84 | BACE1 (0.42) | NPC1RAB9A | |
| SCHEMBL3654102 | 0.78 | P2RX7 (0.51) | ALDH1A1HSD17B10MEN1KMT2AKIT | |
| SCHEMBL3635690 | 0.76 | PIK3CA (0.43) | GPR119 | |
| SCHEMBL1583149 | 0.75 | DPP4 (0.49) | ALDH1A1KDM4EHSD17B10KMT2AHRH1 | |
| SCHEMBL1583770 | 0.75 | HRH3 (0.45) | SCN9AALDH1A1GAAHPGDMEN1 | |
| SCHEMBL3092590 | 0.74 | LMNA (0.39) | KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL1583153 | 0.71 | ROCK2 (0.50) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL1584282 | 0.71 | SCN9A (0.40) | SCN9AGPR119HPGDMEN1KMT2A | |
| SCHEMBL1583384 | 0.70 | KDM4E (0.48) | ALDH1A1KDM4EGAAHPGDMEN1 | |
| SCHEMBL1876108 | 0.70 | POLB (0.47) | ALDH1A1POLBKCNK3KCNK9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150255-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | Smithkline Beecham Corporation (US) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008141065-A1 | QUINOXALINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-20 | — | — | WO | disclosed |