Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.34 |
| ▸ | ADH1C | P00326 | 1/20 | 0.34 |
| ▸ | ADH1A | P07327 | 1/20 | 0.34 |
| ▸ | ADH4 | P08319 | 1/20 | 0.34 |
| ▸ | ADH7 | P40394 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6388427 | 0.97 | EPHX1 (0.41) | EPHX1HPGDKMT2ACES2CES1 | |
| SCHEMBL8602663 | 0.95 | EPHX1 (0.35) | EPHX1HPGDKMT2ACES2CES1 | |
| SCHEMBL4224634 | 0.83 | CYP1A2 (0.38) | EPHX1HPGDKMT2ACES2CES1 | |
| SCHEMBL4449483 | 0.83 | CYP1A2 (0.38) | EPHX1HPGDKMT2ACES2CES1 | |
| SCHEMBL3659402 | 0.83 | CYP1A2 (0.38) | EPHX1HPGDKMT2ACES2CES1 | |
| SCHEMBL11653900 | 0.83 | CYP1A2 (0.38) | EPHX1HPGDKMT2ACES2CES1 | |
| SCHEMBL11402454 | 0.77 | EPHX1 (0.39) | EPHX1HPGDKMT2ACES2CES1 | |
| SCHEMBL8027760 | 0.77 | ALDH1A1 (0.34) | EPHX1 | |
| SCHEMBL20815399 | 0.76 | EPHX1 (0.41) | EPHX1HPGDKMT2ACES2CES1 | |
| SCHEMBL1936361 | 0.72 | EPHX1 (0.39) | EPHX1HPGDKMT2ACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155719-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | disclosed |