Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 7/20 | 0.72 |
| ▸ | TUBB | P07437 | 7/20 | 0.72 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.72 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.72 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.72 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.72 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.72 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.72 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.72 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.72 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.72 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.72 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.72 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.72 |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | TRIM33 | Q9UPN9 | 3/20 | 0.60 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670035 | 0.88 | ROCK2 (0.66) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3668362 | 0.87 | AURKB (0.71) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1964838 | 0.85 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3635068 | 0.84 | ROCK2 (0.77) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28713723 | 0.81 | TUBB4A (0.93) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2995123 | 0.81 | TUBB4A (0.93) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1967297 | 0.80 | TUBB4A (0.84) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL20889527 | 0.79 | PIM1 (0.64) | TRIM33TRIM24ROCK2GSK3BAURKB | |
| SCHEMBL3666498 | 0.78 | AURKB (0.64) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL3664701 | 0.77 | PIM1 (0.57) | ROCK2GSK3BAURKBPIM1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163007-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2015-10-20 | — | — | US | claimed |
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-11-20 | — | — | US | claimed |
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | claimed |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-08-13 | — | — | US | claimed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | claimed |
| US-9163007-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2015-10-20 | — | — | US | disclosed |
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-11-20 | — | — | US | disclosed |
| US-8648069-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2014-02-11 | — | — | US | disclosed |
| EP-2167491-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | Abbott Laboratories (US) | 2010-03-31 | — | — | EP | disclosed |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-08-13 | — | — | US | disclosed |
| WO-2008154241-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | GSK3B, GSK3A, PIM3 | TUBB4A 620/4885TUBB 626/4885TUBA3C 488/4885 |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | GSK3B, GSK3A, PIM3 | TUBB4A 620/4885TUBB 626/4885TUBA3C 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.