Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3442125 | 0.90 | HCRTR1 (0.51) | HCRTR1KCNQ1KMT2AALDH1A1MCOLN3 | |
| SCHEMBL3441492 | 0.82 | HCRTR1 (0.48) | HCRTR1KCNQ1KMT2AALDH1A1MCOLN3 | |
| SCHEMBL699933 | 0.82 | HCRTR1 (0.48) | HCRTR1KCNQ1KMT2AALDH1A1MCOLN3 | |
| SCHEMBL3441729 | 0.81 | OPRM1 (0.54) | HCRTR1KCNQ1KMT2AALDH1A1MCOLN3 | |
| SCHEMBL4436227 | 0.81 | OPRM1 (0.54) | HCRTR1KCNQ1KMT2AALDH1A1MCOLN3 | |
| SCHEMBL3446573 | 0.81 | HCRTR1 (0.53) | HCRTR1KCNQ1KMT2AALDH1A1MCOLN3 | |
| SCHEMBL13660775 | 0.81 | HCRTR1 (0.47) | HCRTR1KCNQ1KMT2AALDH1A1MCOLN3 | |
| SCHEMBL10245869 | 0.81 | HCRTR1 (0.47) | HCRTR1KCNQ1KMT2AALDH1A1MCOLN3 | |
| SCHEMBL4344983 | 0.81 | HCRTR1 (0.52) | HCRTR1KCNQ1KMT2AALDH1A1MCOLN3 | |
| SCHEMBL3441949 | 0.80 | KMT2A (0.54) | HCRTR1KCNQ1KMT2AALDH1A1MCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155678-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC Neurosciences GmbH (DE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008125570-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2008-10-23 | — | — | WO | disclosed |