Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10245869 | 1.00 | HCRTR1 (0.47) | HCRTR1KCNQ1CASP3ALDH1A1GAA | |
| SCHEMBL699933 | 0.88 | HCRTR1 (0.48) | HCRTR1KCNQ1CASP3ALDH1A1GAA | |
| SCHEMBL3441492 | 0.88 | HCRTR1 (0.48) | HCRTR1KCNQ1CASP3ALDH1A1GAA | |
| SCHEMBL14048053 | 0.86 | CASP3 (0.44) | CASP3ALDH1A1KMT2AMCOLN3CASP1 | |
| SCHEMBL3442125 | 0.83 | HCRTR1 (0.51) | HCRTR1KCNQ1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3636162 | 0.81 | HCRTR1 (0.49) | HCRTR1KCNQ1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3446573 | 0.81 | HCRTR1 (0.53) | HCRTR1KCNQ1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL3442128 | 0.81 | KMT2A (0.45) | HCRTR1KCNQ1CASP3ALDH1A1GAA | |
| SCHEMBL2566755 | 0.80 | HCRTR1 (0.42) | HCRTR1KCNQ1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2568566 | 0.79 | CASP3 (0.46) | HCRTR1CASP3CASP1CASP7TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318769-B2 | Substituted sulfonamide compounds | GRUENETHAL GMBH (DE) | 2012-11-27 | — | — | US | disclosed |
| US-8318769-B2 | Substituted sulfonamide compounds | GRUENETHAL GMBH (DE) | 2012-11-27 | — | — | US | disclosed |
| US-20090264400-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-20090264400-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264400-A1 | Substituted Sulfonamide Compounds | BDKRB1, BDKRB2, TRPV1 | HCRTR1 750/4885KCNQ1 262/4885CASP3 2926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.