Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 7/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 6/20 | 0.43 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PLD2 | O14939 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635533 | 0.89 | OPRM1 (0.46) | OPRM1OPRL1OPRK1PLD1DRD2 | |
| SCHEMBL3630082 | 0.89 | OPRM1 (0.46) | OPRM1OPRL1OPRK1PLD1DRD2 | |
| SCHEMBL3636808 | 0.86 | OPRM1 (0.65) | OPRM1OPRL1OPRK1PLD1DRD2 | |
| SCHEMBL3666702 | 0.86 | OPRM1 (0.65) | OPRM1OPRL1OPRK1PLD1DRD2 | |
| SCHEMBL3636203 | 0.86 | BCHE (0.46) | OPRM1OPRL1OPRK1PLD1DRD2 | |
| SCHEMBL3634833 | 0.85 | OPRM1 (0.43) | OPRM1OPRL1OPRK1PLD1DRD2 | |
| SCHEMBL3639475 | 0.83 | OPRM1 (0.61) | OPRM1OPRL1OPRK1PLD1CHRM2 | |
| SCHEMBL3635861 | 0.80 | OPRM1 (0.60) | OPRM1OPRL1OPRK1PLD1DRD2 | |
| SCHEMBL22605916 | 0.77 | OPRM1 (0.54) | OPRM1OPRL1OPRK1DRD2CHRM2 | |
| SCHEMBL3636335 | 0.77 | OPRM1 (0.63) | OPRM1OPRL1OPRK1PLD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155676-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | Commissariat à l'Energie Atomique (FR) | 2010-02-24 | — | — | EP | claimed |
| EP-2150532-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | Evotec AG (DE) | 2010-02-10 | — | — | EP | claimed |
| WO-2008146172-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2008-12-04 | — | — | WO | claimed |
| WO-2008122787-A1 | PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | EVOTEC AG (DE) | 2008-10-16 | — | — | WO | claimed |