Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 9/20 | 0.46 |
| ▸ | DRD4 | P21917 | 9/20 | 0.46 |
| ▸ | DRD3 | P35462 | 7/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 3/20 | 0.42 |
| ▸ | AKT2 | P31751 | 3/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636443 | 0.89 | OPRM1 (0.47) | OPRM1OPRL1OPRK1DRD2DRD4 | |
| SCHEMBL3666702 | 0.84 | OPRM1 (0.65) | OPRM1OPRL1OPRK1DRD2PLD1 | |
| SCHEMBL3636808 | 0.84 | OPRM1 (0.65) | OPRM1OPRL1OPRK1DRD2PLD1 | |
| SCHEMBL3636203 | 0.84 | BCHE (0.46) | OPRM1OPRL1OPRK1DRD2DRD4 | |
| SCHEMBL3634833 | 0.83 | OPRM1 (0.43) | OPRM1OPRL1OPRK1DRD2DRD4 | |
| SCHEMBL3639475 | 0.81 | OPRM1 (0.61) | OPRM1OPRL1OPRK1PLD1 | |
| SCHEMBL3635861 | 0.79 | OPRM1 (0.60) | OPRM1OPRL1OPRK1DRD2DRD4 | |
| SCHEMBL3630082 | 0.78 | OPRM1 (0.46) | OPRM1OPRL1OPRK1DRD2DRD4 | |
| SCHEMBL3636335 | 0.75 | OPRM1 (0.63) | OPRM1OPRL1OPRK1DRD2PLD1 | |
| SCHEMBL3633222 | 0.75 | CALCRL (0.49) | OPRM1OPRL1OPRK1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155676-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | Commissariat à l'Energie Atomique (FR) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008146172-A2 | COMPOUNDS WITH ANTIPARASITIC ACTIVITY, APPLICATIONS THEREOF TO THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY APICOMPLEXANS | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2008-12-04 | — | — | WO | disclosed |