Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 4/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MARK3 | P27448 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635507 | 0.86 | ABL1 (0.34) | LMNASRCFYNFLT3ABL1 | |
| SCHEMBL3938857 | 0.86 | ABL1 (0.32) | LMNAL3MBTL1SRCFYNFLT3 | |
| SCHEMBL3636413 | 0.84 | PIK3CA (0.38) | LMNAALDH1A1RAB9AKMT2ACYP1A2 | |
| SCHEMBL3632163 | 0.84 | CHRNA7 (0.35) | FLT3ABL1ALDH1A1GAARAB9A | |
| SCHEMBL3630824 | 0.80 | KMT2A (0.36) | LMNAL3MBTL1SRCABL1ALDH1A1 | |
| SCHEMBL846971 | 0.67 | STAT6 (0.38) | PPARGEGFRTSHRBTKITK | |
| SCHEMBL3634094 | 0.66 | MDM2 (0.34) | L3MBTL1ALDH1A1RAB9AKMT2AEGFR | |
| SCHEMBL3633598 | 0.66 | KCNQ3 (0.38) | L3MBTL1ABL1RAB9AKMT2AEGFR | |
| SCHEMBL3634212 | 0.65 | LMNA (0.42) | LMNAL3MBTL1ALDH1A1PPARGGAA | |
| SCHEMBL3630762 | 0.65 | KMT2A (0.45) | LMNAALDH1A1RAB9AKMT2AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |