Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 8/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.46 |
| ▸ | ABAT | P80404 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8679779 | 0.89 | ERN1 (0.59) | ALDH1A1AOX1ERN1TDP1TRIM24 | |
| SCHEMBL5155052 | 0.88 | ALDH1A1 (0.57) | CA1CA2ALDH1A1AOX1ERN1 | |
| SCHEMBL6291227 | 0.81 | SRC (0.53) | CA1CA2ALDH1A1AOX1ERN1 | |
| SCHEMBL1050289 | 0.81 | ALDH1A1 (0.59) | ALDH1A1AOX1ERN1TDP1TRIM24 | |
| SCHEMBL29361496 | 0.81 | ALDH1A1 (0.59) | ALDH1A1AOX1ERN1TDP1TRIM24 | |
| SCHEMBL4615908 | 0.81 | ERN1 (0.59) | CA1CA2ALDH1A1ERN1TDP1 | |
| SCHEMBL28064053 | 0.81 | ERN1 (0.58) | CA1CA2ALDH1A1ERN1TDP1 | |
| SCHEMBL1159670 | 0.79 | TUBB1 (0.49) | CA1CA2ALDH1A1AOX1TDP1 | |
| SCHEMBL2807788 | 0.79 | TPMT (0.54) | CA1CA2ALDH1A1AOX1ERN1 | |
| SCHEMBL2808932 | 0.79 | TPMT (0.54) | CA1CA2ALDH1A1AOX1ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946482-B1 | METHOD FOR PREPARING A 4-HYDROXYBENZALDEHYDE AND DERIVATIVES | RHODIA CHIMIE SA (FR) | 2002-07-24 | — | — | EP | claimed |
| US-6184421-B1 | SELECTIVE OXIDATION, TO A CARBOXY GROUP, OF THE GROUP IN THE 2 POSITION WITH RESPECT TO THE HYDROXYL GROUPS OF A MIXTURE OF PHENOLS HAVING FORMYL AND/OR HYDROXYMETHYL GROUPS IN POSITIONS 2 OR 4; PREPARING VANILLIN AND ETHYL VANILLIN | RHODIA CHIMIE (FR) | 2001-02-06 | — | — | US | claimed |
| EP-0773919-B1 | METHOD FOR PREPARING 3-CARBOXY-4-HYDROXYBENZALDEHYDES AND DERIVATIVES THEREOF | RHODIA CHIMIE SA (FR) | 2000-09-20 | — | — | EP | claimed |
| EP-0946482-A1 | METHOD FOR PREPARING A 4-HYDROXYBENZALDEHYDE AND DERIVATIVES | RHODIA CHIMIE (FR) | 1999-10-06 | — | — | EP | claimed |
| US-5783737-A | Process for the preparation of 3-carboxy-4-hydroxybenzaldehides and derivatives thereof | RHONE-POULENC CHIMIE (FR) | 1998-07-21 | — | — | US | claimed |
| WO-1998022419-A1 | METHOD FOR PREPARING A 4-HYDROXYBENZALDEHYDE AND DERIVATIVES | RHODIA CHIMIE (FR) | 1998-05-28 | — | — | WO | claimed |
| EP-0773919-A1 | METHOD FOR PREPARING 3-CARBOXY-4-HYDROXYBENZALDEHYDES AND DERIVATIVES THEREOF | RHONE-POULENC CHIMIE (FR) | 1997-05-21 | — | — | EP | claimed |
| WO-1996037454-A1 | METHOD FOR PREPARING 3-CARBOXY-4-HYDROXYBENZALDEHYDES AND DERIVATIVES THEREOF | RHONE-POULENC CHIMIE (FR) | 1996-11-28 | — | — | WO | claimed |
| EP-0044260-B1 | PROCESS FOR THE PREPARATION OF POLYPHENOLS OPTIONALLY SUBSTITUTED BY AN ALDEHYDE GROUP | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1984-04-11 | — | — | EP | claimed |
| US-4435601-A | OXIDATION WITH HYDROGEN PEROXIDE IN ALKALI OR ALKALINE METAL BASE | RHONE-POULENC INDUSTRIES (FR) | 1984-03-06 | — | — | US | claimed |
| US-9981901-B2 | IRE-1α inhibitors | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2018-05-29 | — | — | US | disclosed |
| US-20170152206-A1 | IRE-1alpha INHIBITORS | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2017-06-01 | — | — | US | disclosed |
| US-9546149-B2 | IRE-1α inhibitors | MANNKIND CORPORATION (US) | 2017-01-17 | — | — | US | disclosed |
| CN-103450077-B | IRE-1 alpha inhibitor | 满康德股份有限公司 | 2016-07-06 | — | — | CN | disclosed |
| US-20160168116-A1 | IRE-1alpha Inhibitors | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2016-06-16 | — | — | US | disclosed |
| US-5783737-A | Process for the preparation of 3-carboxy-4-hydroxybenzaldehides and derivatives thereof | RHONE-POULENC CHIMIE (FR) | 1998-07-21 | — | — | US | disclosed |
| WO-1998022419-A1 | METHOD FOR PREPARING A 4-HYDROXYBENZALDEHYDE AND DERIVATIVES | RHODIA CHIMIE (FR) | 1998-05-28 | — | — | WO | disclosed |
| EP-0773919-A1 | METHOD FOR PREPARING 3-CARBOXY-4-HYDROXYBENZALDEHYDES AND DERIVATIVES THEREOF | RHONE-POULENC CHIMIE (FR) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996037454-A1 | METHOD FOR PREPARING 3-CARBOXY-4-HYDROXYBENZALDEHYDES AND DERIVATIVES THEREOF | RHONE-POULENC CHIMIE (FR) | 1996-11-28 | — | — | WO | disclosed |
| US-4435601-A | OXIDATION WITH HYDROGEN PEROXIDE IN ALKALI OR ALKALINE METAL BASE | RHONE-POULENC INDUSTRIES (FR) | 1984-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152206-A1 | IRE-1alpha INHIBITORS | XBP1, DDIT3, ERN1 | CA1 3793/4885CA2 3345/4885ALDH1A1 2586/4885 |
| US-20160168116-A1 | IRE-1alpha Inhibitors | XBP1, DDIT3, ERN1 | CA1 3793/4885CA2 3345/4885ALDH1A1 2586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.