SCHEMBL5155052

SCHEMBL5155052

COc1c(O)cc(C=O)cc1O

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.57
AOX1 Q06278 1/20 0.57
TDP1 Q9NUW8 2/20 0.56
TRIM24 O15164 2/20 0.52
TRIM33 Q9UPN9 2/20 0.52
HPGD P15428 1/20 0.52
ALDH5A1 P51649 1/20 0.52
ABAT P80404 1/20 0.52
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
KDM4E B2RXH2 1/20 0.46
PTGS2 P35354 1/20 0.46
RAB9A P51151 1/20 0.46
ERN1 O75460 2/20 0.42
TYR P14679 1/20 0.42
TSHR P16473 1/20 0.42
TUBB1 Q9H4B7 2/20 0.42
SLC22A2 O15244 1/20 0.42
SLCO2B1 O94956 1/20 0.42
TUBB4A P04350 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6291227 0.88 SRC (0.53) ALDH1A1AOX1TDP1TRIM24TRIM33
SCHEMBL1050289 0.88 ALDH1A1 (0.59) ALDH1A1AOX1TDP1TRIM24TRIM33
SCHEMBL3637463 0.88 CA1 (0.55) ALDH1A1AOX1TDP1TRIM24TRIM33
SCHEMBL29361496 0.88 ALDH1A1 (0.59) ALDH1A1AOX1TDP1TRIM24TRIM33
SCHEMBL2808932 0.86 TPMT (0.54) ALDH1A1AOX1TDP1TRIM24TRIM33
SCHEMBL2807788 0.86 TPMT (0.54) ALDH1A1AOX1TDP1TRIM24TRIM33
SCHEMBL31132205 0.86 TPMT (0.54) ALDH1A1AOX1TDP1TRIM24TRIM33
SCHEMBL1159670 0.86 TUBB1 (0.49) ALDH1A1AOX1TDP1TRIM24TRIM33
SCHEMBL27426702 0.86 TPMT (0.54) ALDH1A1AOX1TDP1TRIM24TRIM33
SCHEMBL8155228 0.83 ALDH1A1 (0.46) ALDH1A1AOX1TDP1TRIM24TRIM33

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070130702-A1 Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative L'OREAL S.A. 2007-06-14 US claimed
US-7204857-B1 Dyeing method using a specific active methylene compound and a compound selected among a specific aldehyde, a specific ketone, a quinone and a di-imino-isoindoline or 3-amino-isoindolone derivative L'OREAL S.A. (FR) 2007-04-17 US claimed
US-6635090-B1 Dyeing method using a specific cationic derivative and a compound selected among a specific aldehyde, a specific ketone, a quinone and a di-imino-isoindoline or 3-amino-isoindolone derivative L'OREAL, S.A. (FR) 2003-10-21 US claimed
US-6458168-B1 Hair dyeing method using an aliphatic cationic amine and compound chosen from an aldehyde, a ketone, a quinone, a di-imino-isoindoline, and a 3-aminoisoindolone derivative L'OREAL S.A. (FR) 2002-10-01 US claimed
US-6451067-B1 HAIR DYE MIXTURE L'OREAL S.A. (FR) 2002-09-17 US claimed
EP-0006458-B1 N1-BENZOYL-N2-PHENYL-1,3-DIAMINOPROPANE-2-OLS AND THEIR SALTS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM Kali-Chemie Pharma GmbH (DE) 1981-10-07 EP claimed
US-4271193-A PROPHYLAXIS AND TREATMENT OF GASTRITIS KALI-CHEMIE PHARMA GMBH (DE) 1981-06-02 US claimed
US-12195450-B2 Small molecule neutral sphingomyelinase 2 (nSMase2) inhibitors THE JOHNS HOPKINS UNIVERSITY (US) 2025-01-14 US disclosed
US-20240130988-A1 Use of stilbene compounds in the preparation of anti-tumor drugs GUANGZHOU ANHAO PHARMACEUTICAL TECHNOLOGY CO LTD. (CN) 2024-04-25 US disclosed
EP-4342463-A1 STILBENE COMPOUNDS FOR USE IN THE TREATMENT OF TUMOUR AND EYE DISEASES Guangzhou AnHao Pharmaceutical Technology Co., Ltd. (CN) 2024-03-27 EP disclosed
CN-115444841-B Application of stilbene compounds in preparation of antitumor drugs 广州安好医药科技有限公司 2023-05-12 CN disclosed
CN-115444841-A Application of stilbene compound in preparation of antitumor drugs 广州安好医药科技有限公司 2022-12-09 CN disclosed
US-20220119374-A1 SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (nSMase2) INHIBITORS THE JOHNS HOPKINS UNIVERSITY 2022-04-21 US disclosed
EP-1056435-A1 DYEING METHOD USING AN ALIPHATIC CATIONIC AMINE AND A ALDEHYDE OR KETONE OR QUINONE OR DI-IMINO-ISOINDOLINE OR 3-AMINO-ISOINDOLONE DERIVATIVES L'OREAL (FR) 2000-12-06 EP disclosed
EP-1056433-A1 DYEING METHOD USING A SPECIFIC ACTIVE METHYLENE COMPOUND AND A COMPOUND SELECTED AMONG A SPECIFIC ALDEHYDE, A SPECIFIC KETONE, A QUINONE AND A DI-IMINO-ISOINDOLINE OR 3-AMINO-ISOINDOLONE DERIVATIVE L'OREAL (FR) 2000-12-06 EP disclosed
WO-2000038641-A1 DYEING METHOD USING AN ALIPHATIC CATIONIC AMINE AND A ALDEHYDE OR KETONE OR QUINONE OR DI-IMINO-ISOINDOLINE OR 3-AMINO-ISOINDOLONE DERIVATIVES L'OREAL (FR) 2000-07-06 WO disclosed
WO-2000038640-A1 HAIR DYEING METHOD USING AN ALIPHATIC CATIONIC AMINE AND A ALDEHYDE OR KETONE OR QUINONE OR DI-IMINO-ISOINDOLINE OR 3-AMINO-ISO-INDOLONE DERIVATIVES L'OREAL (FR) 2000-07-06 WO disclosed
WO-2000038639-A1 DYEING METHOD USING A SPECIFIC CATIONIC DERIVATIVE AND A COMPOUND SELECTED AMONG A SPECIFIC ALDEHYDE, A SPECIFIC KETONE, A QUINONE AND A DI-IMINO-ISOINDOLINE OR 3-AMINO-ISOINDOLONE DERIVATIVE L'OREAL (FR) 2000-07-06 WO disclosed
WO-2000038638-A1 DYEING METHOD USING A SPECIFIC ACTIVE METHYLENE COMPOUND AND A COMPOUND SELECTED AMONG A SPECIFIC ALDEHYDE, A SPECIFIC KETONE, A QUINONE AND A DI-IMINO-ISOINDOLINE OR 3-AMINO-ISOINDOLONE DERIVATIVE L'OREAL (FR) 2000-07-06 WO disclosed
US-4695659-A QUATERNARY AMMONIUM IODIDE, ALUMINUM IODIDE CHEMICAL DYNAMICS DEVELOPMENT AB (SE) 1987-09-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12195450-B2 Small molecule neutral sphingomyelinase 2 (nSMase2) inhibitors SMPD2, SPTLC2, SGMS2 ALDH1A1 3995/4885AOX1 4089/4885TDP1 826/4885
US-20070130702-A1 Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative KRT18, NDUFB5, NDUFB7 ALDH1A1 83/4885AOX1 235/4885TDP1 3452/4885
US-20240130988-A1 Use of stilbene compounds in the preparation of anti-tumor drugs CD4, CD81, NFATC1 ALDH1A1 1799/4885AOX1 2814/4885TDP1 2958/4885
US-20220119374-A1 SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (nSMase2) INHIBITORS SMPD2, SPTLC2, SGMS2 ALDH1A1 3995/4885AOX1 4089/4885TDP1 826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.