Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736600 | 0.80 | HTT (1.00) | HTTNPSR1CHEK1TSHRKMT2A | |
| SCHEMBL916128 | 0.80 | NPSR1 (1.00) | HTTNPSR1CHEK1TSHRKMT2A | |
| SCHEMBL914710 | 0.79 | GAA (1.00) | HTTNPSR1CHEK1TSHRKMT2A | |
| SCHEMBL23209624 | 0.77 | HTT (0.58) | HTTNPSR1CHEK1TSHRKMT2A | |
| SCHEMBL4694133 | 0.77 | HTT (0.67) | HTTNPSR1CHEK1TSHRKMT2A | |
| SCHEMBL4691404 | 0.75 | HTT (0.65) | HTTNPSR1CHEK1TSHRKMT2A | |
| SCHEMBL14459794 | 0.74 | HTT (0.63) | HTTNPSR1CHEK1TSHRKMT2A | |
| SCHEMBL968635 | 0.73 | SIGMAR1 (0.67) | SIGMAR1KCNH2 | |
| SCHEMBL13074167 | 0.73 | KDM4E (0.63) | HTTNPSR1CHEK1TSHRKMT2A | |
| SCHEMBL18750530 | 0.73 | SIGMAR1 (0.54) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572698-B1 | 3-SUBSTITUTED 3,4-DIHYDRO-THIENO¬2,3-D PYRIMIDINE-4-ONE-DERIVATIVES, PRODUCTION AND USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2008-07-02 | — | — | EP | claimed |
| EP-4308574-A1 | NEW 5,6,7,8-TETRAHYDROPYRIDO[4',3':4,5] THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE DERIVATIVES AS SIGMA LIGANDS | Acondicionamiento Tarrasense (ES) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022195022-A1 | NEW 5,6,7,8-TETRAHYDROPYRIDO[4',3':4,5] THIENO[2,3-d]PYRIMIDIN-4(3H)-ONE DERIVATIVES AS SIGMA LIGANDS | ACONDICIONAMIENTO TARRASENSE (ES) | 2022-09-22 | — | — | WO | disclosed |
| EP-2162451-A2 | PIPERAZINYL OXOALKYL TETRAHYDRO-BETA-CARBOLINES AND RELATED ANALOGUES | Neurogen Corporation (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2009003003-A2 | PIPERAZINYL OXOALKYL TETRAHYDRO-BETA-CARBOLINES AND RELATED ANALOGUES | NEUROGEN CORPORATION (US) | 2008-12-31 | — | — | WO | disclosed |