Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 6/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640630 | 0.91 | ALOX5AP (0.48) | FEN1ALOX5APL3MBTL1ALDH1A1POLB | |
| SCHEMBL3643843 | 0.91 | ALOX5AP (0.46) | FEN1ALOX5APL3MBTL1ALDH1A1POLB | |
| SCHEMBL3647003 | 0.89 | DHFR (0.39) | FEN1ALOX5APALDH1A1DHFRPIK3CD | |
| SCHEMBL3638260 | 0.89 | ALDH1A1 (0.45) | FEN1ALOX5APALDH1A1DHFRPIK3CD | |
| SCHEMBL3646170 | 0.88 | ALOX5AP (0.51) | FEN1ALOX5APALDH1A1MEN1HTT | |
| SCHEMBL3642925 | 0.88 | FEN1 (0.48) | FEN1ALOX5APALDH1A1KCNH2PIK3CA | |
| SCHEMBL3640410 | 0.86 | ALOX5AP (0.48) | FEN1ALOX5APALDH1A1DHFRHTT | |
| SCHEMBL3646702 | 0.85 | ALOX5AP (0.50) | FEN1ALOX5APDHFRPIK3CDPIK3CA | |
| SCHEMBL3643601 | 0.79 | SMN1; SMN2 (0.48) | FEN1ALOX5APL3MBTL1ALDH1A1POLB | |
| SCHEMBL3644204 | 0.78 | PIK3CD (0.55) | FEN1ALOX5APDHFRPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263585-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-09-11 | — | — | US | disclosed |
| EP-2173722-B1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS | NOVARTIS AG (CH) | 2012-08-29 | — | — | EP | disclosed |
| EP-2173722-A2 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS | Novartis Ag (CH) | 2010-04-14 | — | — | EP | disclosed |
| US-20090163463-A1 | Organic Compounds | NOVARTIS AG | 2009-06-25 | — | — | US | disclosed |
| WO-2009013348-A2 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS | NOVARTIS AG (CH) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163463-A1 | Organic Compounds | PIK3C3, PIK3CA, MTOR | FEN1 4194/4885ALOX5AP 3790/4885L3MBTL1 4096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.