Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 8/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.44 |
| ▸ | IGF1R | P08069 | 5/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3511487 | 0.86 | GPR119 (0.41) | INSRALKIGF1RPLK4AURKA | |
| SCHEMBL16887726 | 0.85 | ALK (0.56) | ACLYINSRALKIGF1RPLK4 | |
| SCHEMBL3676371 | 0.82 | ALK (0.53) | ACLYINSRALKIGF1RPLK4 | |
| SCHEMBL12466224 | 0.81 | HRH4 (0.46) | ACLYINSRALKIGF1RPLK4 | |
| SCHEMBL12467704 | 0.81 | HRH4 (0.46) | ACLYINSRALKIGF1RPLK4 | |
| SCHEMBL3640173 | 0.80 | INSR (0.44) | ACLYINSRALKIGF1RPLK4 | |
| SCHEMBL12682537 | 0.76 | ALK (0.54) | INSRALKIGF1RPLK4AURKA | |
| SCHEMBL12466522 | 0.76 | BTK (0.45) | INSRALKIGF1RBTK | |
| SCHEMBL12466518 | 0.76 | BTK (0.45) | INSRALKIGF1RBTK | |
| SCHEMBL17848239 | 0.76 | ALK (0.53) | INSRALKIGF1RPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176231-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009013126-A1 | SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-01-29 | — | — | WO | disclosed |