Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817106 | 1.00 | CHRM4 (0.47) | CHRM4ALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL2817840 | 0.94 | POLB (0.44) | CHRM4ALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL3641058 | 0.94 | KMT2A (0.41) | CHRM4ALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL2822473 | 0.94 | KMT2A (0.41) | CHRM4ALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL2820467 | 0.94 | LMNA (0.49) | CHRM4ALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL3979720 | 0.88 | NPBWR1 (0.42) | ALDH1A1MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL2820035 | 0.87 | TACR3 (0.44) | CHRM4ALDH1A1SMN1; SMN2POLBLMNA | |
| SCHEMBL3641111 | 0.87 | TACR3 (0.44) | CHRM4ALDH1A1SMN1; SMN2POLBLMNA | |
| SCHEMBL3805658 | 0.86 | LMNA (0.44) | CHRM4ALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL2822151 | 0.85 | NPC1 (0.51) | ALDH1A1SMN1; SMN2POLBLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155672-A1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | claimed |
| WO-2008148689-A1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-11 | — | — | WO | claimed |
| EP-2155672-A1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148689-A1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-11 | — | — | WO | disclosed |