Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 15/20 | 0.49 |
| ▸ | MGLL | Q99685 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzo[D]Isoxazole SCHEMBL3643818 | 0.90 | FAAH (0.56) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| Benzo[D]Isoxazole SCHEMBL3642872 | 0.89 | FAAH (0.61) | FAAH | |
| Benzo[D]Isoxazole SCHEMBL3645456 | 0.89 | FAAH (0.56) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| Benzo[D]Isoxazole SCHEMBL3642701 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| Benzo[D]Isoxazole SCHEMBL3636254 | 0.84 | ALDH1A1 (0.49) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL3636961 | 0.79 | KDM4E (0.61) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL3644401 | 0.78 | KDM4E (0.79) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL3348670 | 0.77 | FAAH (0.52) | KDM4EALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL4113870 | 0.77 | FAAH (0.80) | FAAH | |
| SCHEMBL17276823 | 0.74 | FAAH (0.65) | KDM4EALDH1A1LMNAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164493-A2 | HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE | Janssen Pharmaceutica, N.V. (BE) | 2010-03-24 | — | — | EP | claimed |
| WO-2008153752-A2 | HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-18 | — | — | WO | claimed |