Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 14/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 2/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1577350 | 0.88 | GRM6 (0.47) | BDKRB1BRS3GRM6ALDH1A1 | |
| SCHEMBL8179672 | 0.84 | BDKRB1 (0.58) | BDKRB1MAPTALDH1A1TSHRMAPK1 | |
| SCHEMBL27379045 | 0.80 | SLC6A4 (0.46) | BDKRB1GRM6ALDH1A1 | |
| SCHEMBL7930737 | 0.79 | MEN1 (0.50) | BRS3 | |
| SCHEMBL18131333 | 0.79 | CES2 (0.44) | MAPTCYP2C19GRM6 | |
| SCHEMBL517 | 0.76 | SLC6A3 (0.50) | MAPTCYP1A2CYP2C19BRS3GRM6 | |
| SCHEMBL9318442 | 0.76 | MAOB (0.46) | — | |
| SCHEMBL17374999 | 0.75 | CA12 (0.48) | MAPTGRM6 | |
| SCHEMBL6356349 | 0.75 | KMT2A (0.46) | MAPTGRM6ALDH1A1 | |
| SCHEMBL27371068 | 0.75 | APP (0.43) | MAPTGRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162442-A1 | DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008153857-A1 | DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-12-18 | — | — | WO | disclosed |