Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.42 |
| ▸ | MC1R | Q01726 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | VHL | P40337 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820776 | 0.95 | MAOA (0.46) | MAOAMAOBKDM4EMC3RMC1R | |
| SCHEMBL2818883 | 0.83 | CYP3A4 (0.50) | MAOAMAOBKDM4ECYP3A4KMT2A | |
| SCHEMBL4249938 | 0.83 | CYP3A4 (0.50) | MAOAMAOBKDM4ECYP3A4KMT2A | |
| SCHEMBL1440329 | 0.83 | CYP3A4 (0.50) | MAOAMAOBKDM4ECYP3A4KMT2A | |
| SCHEMBL15325590 | 0.83 | CYP3A4 (0.50) | MAOAMAOBKDM4ECYP3A4KMT2A | |
| SCHEMBL24938939 | 0.83 | CYP3A4 (0.50) | MAOAMAOBKDM4ECYP3A4KMT2A | |
| SCHEMBL5368566 | 0.83 | CYP3A4 (0.50) | MAOAMAOBKDM4ECYP3A4KMT2A | |
| SCHEMBL19408855 | 0.83 | CYP3A4 (0.50) | MAOAMAOBKDM4ECYP3A4KMT2A | |
| Hydrochloric Acid SCHEMBL6951431 | 0.82 | CYP3A4 (0.49) | MAOAMAOBKDM4ECYP3A4KMT2A | |
| SCHEMBL2817870 | 0.80 | ALDH1A1 (0.47) | MAOAMAOBKDM4EMC3RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155672-A1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148689-A1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-11 | — | — | WO | disclosed |